What You Should Know Before Starting HRT for Perimenopause

Perimenopause brings hormonal changes that can disrupt your daily life—irregular periods, hot flashes, mood swings, and sleep problems are just the beginning. Hormone replacement therapy (HRT) offers relief for many women navigating this transition, but starting treatment requires understanding the options, safety considerations, and what to expect.

This comprehensive Q&A guide answers the most common questions about HRT during perimenopause. Whether you're wondering if HRT is right for you, confused about the difference between birth control and HRT, or trying to understand progesterone dosing, you'll find evidence-based answers from menopause experts.

We've organized questions into categories covering everything from diagnosis and testing to choosing delivery methods and monitoring your treatment. Use the search function to find specific topics or browse by category to learn about HRT safety, hormone options, and how to work with your healthcare provider for optimal results.

New to HRT?

Start with our HRT 101 Complete Guide for foundational knowledge. Already in menopause? Visit our HRT for Menopause Q&A. For broader perimenopause topics, see our General Menopause Q&A.

The information provided on this page is for educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. Every woman’s experience with perimenopause and menopause is unique. If you have concerns or symptoms affecting your health, please consult a qualified healthcare provider for personalized guidance and care. MenoHello does not endorse any specific treatments or products mentioned here.